At cLose, Sensex ended 195.71 points lower or 0.34% at 57064.87, and the Nifty shed 81.40 points or 0.48% at 16972.60 after US pharma major Moderna warned that Covid-19 shots seemed less effective against Omicron. Power Grid was the top Sensex gainer, followed by Titan, State Bank of India, and Bajaj Finance. While Tata Steel, Kotak Mahindra Bank, Reliance Industries, and Bajaj Auto are the top losers. About 1675 shares have advanced, 1383 shares declined, and 112 shares are unchanged. Among the sectors, the metal index fell over 2 percent followed by banks, auto, and power while IT, Realty, and FMCG closed in the green. while India VIX was down more than 5%.The BSE Midcap index gained 0.3 percent, while the Smallcap index rallied 1.5 percent.